What does genistein do?

 Genistein (genistein) inhibits the proliferation, growth and metastasis of malignant cells by inhibiting the activities of protein tyrosine kinase (PTK) and topoisomerase II, regulating oncogenes, inhibiting specific cell cycles, and inhibiting the proliferation, growth and metastasis of malignant cells through 7 pathways .

1. Directly kill tumor cells

By inhibiting the activity of tyrosine protein kinase and topoisomerase 11, it can prevent the signal transduction pathway of tumor cell growth and change gene expression, thereby inhibiting the proliferation of malignant cells and directly killing tumor cells.

2. Reversing tumor cells into normal cells

By inhibiting the activity of topoisomerase, the expression of differentiation-related genes can be changed, and the phosphorylation level can be reduced by inhibiting the activity of tyrosine protein kinase, and cell differentiation can be induced, thereby inducing tumor cells to reverse into normal cells.

3. Inhibit angiogenesis and starve tumor cells

It inhibits the growth of tumor blood vessels, interferes, blocks and destroys the new blood vessel network, cuts off the nutrient supply and waste excretion channels of tumor cells, starves tumor cells, and achieves the goal of regressing tumors and inhibiting metastasis.

4. Apoptotic tumor cells

By inhibiting tyrosine protein kinase, changing gene expression, inducing apoptosis, by inhibiting topoisomerase, causing DNA damage in tumor cells, inducing P53 gene expression, thereby inducing programmed cell death of tumor cells.

5. Inhibit cell growth cycle

By damaging DNA, regulating the expression of related genes, blocking the cell growth cycle in the non-proliferating G1 and G2 phases, thereby inhibiting the growth and proliferation of tumor cells.

6. Antioxidant

It can inhibit tumor by increasing the activity of antioxidant enzymes in plasma and tissues, reducing the level of reactive oxygen species in tumor cells, and protecting DNA from oxidative attack. By scavenging free radicals and hydrogen peroxide, it can prevent the damage of carcinogens to the body, and reduce the adverse reactions of radiotherapy and chemotherapy.

7. Inhibit excess estrogen

Genistein (genistein) increases the synthesis of estrogen-binding globulin, thereby reducing the bioavailability of hormones, reducing the proliferative activity of estrogens, and reducing the occurrence of hormone-related tumors.