Apigenin is a bioflavonoid compound that can be found in various plants and herbs. Chamomile tea is very rich and works to reduce anxiety when taken in high doses. In higher doses, it can be a sedative.
Efficacy and role
Apigenin is also a very potent anticancer compound. It is highly selective for cancer cells and can induce apoptosis in cancer cells with high selectivity without damaging normal cells.
It also has a very high safety threshold, and active (anticancer) doses can be obtained by eating a diet rich in vegetables and fruits. Apigenin beneficially affects most types of cancer.
Apigenin may exert neuroprotective effects against excitotoxicity and prevent calcium accumulation in neural mitochondria. Apigenin and two glucopyranosides of apigenin can exert antidiabetic effects in the body.
Apigenin exerts its anti-inflammatory effect through the influence of lipopolysaccharide by inhibiting NO synthase and COX2 enzymes in macrophages.
Apigenin also has the effect of inhibiting the production of interleukin-4. Apigenin can also inhibit TNFα elevation by interfering with NF-kb transcription and potential TNFα-induced upregulation of adhesion molecule
1. Apigenin is one of the known bioflavonoid compounds with high selectivity in inducing selective apoptosis of cancer cells in vivo.
Like other bioflavonoids, apigenin reduces oxidative stress, induces cell cycle inhibition, increases the efficacy of liver detoxification enzymes, and to some extent acts as an anti-inflammatory.
Laboratory animal studies have shown that apigenin is antimutagenic against exogenous toxins and bacterial responses, and plays a direct role in metal chelation, free radical scavenging, and induction of phase II detoxification enzymes such as glutathione,
It is also an inhibitor of ornithine decarboxylase, which may promote the growth of certain tumors. The presence of apigenin in the body also appears to be acutely protective against carcinogenic injury.
application
Apigenin is widely used in cosmetics: the absorption of ultraviolet rays by apigenin is concentrated in the B region (wavelength between 280~320nm), which is strong absorption and can be used in sunscreen series cosmetics;
The absorption in the A region (wavelength between 320~400nm) is small, so low concentration of apigenin can be used as a skin darkening agent and added to tanning oil;
Can be used as a pigment stabilizer in cosmetics, the recommended dosage is 1%; apigenin can be used in creams;
It can be compounded with vitamin B1, vitamin B6, vitamin B12, vitamin C, etc.; it can also be compounded with plant essential oils such as chamomile oil, calendula oil, almond oil, etc.;
High concentrations of apigenin can inhibit the activity of melanocytes, and can be added to sunscreens, face creams, essences, lotions, masks and other cosmetics; can be used in shampoos and conditioners.
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